This in-depth conversation between Dr. Andrew Huberman and Dr. David Sinclair explores the cellular mechanisms of aging and practical interventions to slow or even reverse it. They discuss how lifestyle factors like fasting, exercise, cold exposure, and key supplements (e.g. resveratrol, NAD boosters, metformin) can promote autophagy and reduce biological age, as well as emerging longevity technologies and biomarkers to track aging. By the end, you’ll have a
science-backed playbook of strategies to extend healthspan and lifespan.